Quadrivalent Human Papillomavirus Vaccine and High-Grade Vulvovaginal Lesions.

ABSTRACT:

Importance

Human papillomavirus (HPV) vaccination has been associated with reduced risk of high-grade cervical lesions. However, evidence on its association with high-grade vulvovaginal lesions remains scarce.

Objective

To evaluate the association between quadrivalent HPV vaccination and high-grade vulvovaginal lesions and assess the population-level incidence reduction among birth cohorts eligible for various vaccination programs.

Design, setting, and participants

This population-based cohort study included women who were born between 1985 and 1998 and resided in Sweden between 2006 and 2022. Eligible participants had not previously received an HPV vaccination and did not have high-grade vulvovaginal lesions. Data were analyzed from February to October 2025.

Expos

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12921526 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature