Prospective Registry and Meta-Analysis of Particle Therapy for Hepatocellular Carcinoma: Clinical Outcomes and Real-World Impact.

ABSTRACT:

Background and aims

This study aimed to evaluate the clinical efficacy of particle therapy for hepatocellular carcinoma (HCC) by integrating a prospective registry and a systematic meta-analysis. Our findings also reflect the real-world impact of this evidence, which contributed to the national health insurance approval of particle therapy for HCC tumors ≥ 4 cm in Japan.

Methods

Patients who received particle therapy for HCC from May 2016 to June 2018 were registered. Ninety studies (25 particle therapy, 26 non-SBRT, 36 SBRT, 3 studies reporting multiple modalities) were selected.

Results

A total of 836 cases (proton beam therapy 576, carbon therapy 260) were examined. The median overall survival (OS) was 53.7 months (95% CI 47.4-NA). The 1-, 2-, 3- and 4-year OS rate

SUBMITTER: Mizumoto M 

PROVIDER: S-EPMC12921530 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature