Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports.

ABSTRACT:

Background

Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, premalignant disease with a progression rate of 0.5%-1% per year to multiple myeloma. It can rarely present with significant ocular symptoms in the context of crystalline keratopathy, necessitating medical and surgical interventions. Lattice corneal dystrophy Type I (LCD-1), a rare inherited disorder caused by mutations of TGFBI, manifests with amyloid deposition within the corneal stroma and causes visual impairment. Here, we pictorially highlight protein deposition using immunofluorescence in two representative cases, both having undergone penetrating keratoplasty for blurry vision.

Methods

Medical records were reviewed. Hematoxylin and eosin, special staining, immunohistochemis

SUBMITTER: Zengin S 

PROVIDER: S-EPMC12921536 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature