Aggressive Glioblastoma Cells Enhance the Migratory Persistence and Velocity of Less Aggressive Cells to Promote Tumor Dissemination.

ABSTRACT: Glioblastoma multiforme (GBM) is a highly lethal brain cancer driven by aggressive invasion. Epidermal growth factor receptor (EGFR) is frequently amplified in GBM, with the EGFRvIII mutant enhancing the infiltrative features of EGFRwt-overexpressing cells. Previously, we identified Src as a key cell-cell communication mediator between EGFRvIII and EGFRwt cells. However, a quantitative biophysical characterization of how EGFRvIII induces this increased infiltration, specifically detailing altered movement parameters and the underlying mechanisms, remains lacking. Using bulk cell culture and 2-cell microfluidic chips, we quantitatively analyzed the motility of EGFRwt-overexpressing and EGFRvIII-expressing GBM cells. We observed that EGFRvIII cells exhibit higher migration velocity and persi

SUBMITTER: Mohand FA 

PROVIDER: S-EPMC12921552 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature