Flexible Electrochemical Biosensor for Non-Invasive, on-Site Cortisol Monitoring in Sweat and Saliva.

ABSTRACT: Chronic stress is a critical public health concern with strong links to both mental and physical health. Excessive stress alters brain architecture and stimulates the adrenal gland to release cortisol, a key biomarker of stress. Conventional cortisol measurements rely on invasive, laboratory-based methods that are unsuitable for real-time, point-of-care testing. This study reports the development of a noninvasive, flexible electrochemical biosensor for the selective detection of cortisol in human sweat and saliva. The sensor was fabricated on a polyethylene terephthalate (PET) substrate coated with indium tin oxide (ITO) and functionalized with gold nanoparticles (AuNPs) to enhance conductivity and surface area. AnteoBind chemistry was employed for oriented immobilization of monoclonal ant

SUBMITTER: Fande S 

PROVIDER: S-EPMC12921587 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature