The ketogenic diet alters microbiome-metabolome profiles to improve West syndrome therapy.

ABSTRACT:

Importance

The ketogenic diet (KD) is effective in managing epilepsy, particularly West syndrome (WS); however, the role of gut microbiome (GM) and metabolome in its efficacy remains unclear. Understanding these mechanisms could optimize the KD for WS treatment.

Objective

To identify microbiome-metabolome signatures associated with KD efficacy in WS by analyzing changes in GM composition and metabolic pathways.

Methods

Fecal samples were collected from WS patients (n = 16) and healthy children (n = 24). Metagenome and metabolome analyses were performed to assess GM composition and metabolic profiles.

Results

WS patients showed GM imbalances compared to healthy children. Disease status contributed sufficiently to the GM. The abundance of Bactero

SUBMITTER: Xie G 

PROVIDER: S-EPMC12921638 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature