Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the SIRT1/FOXO1/SLC7A11/GPX4 Pathway.

ABSTRACT:

Background

Epilepsy represents a prevalent neurological disorder. Currently, ferroptosis has been reported to be intricately linked to epilepsy onset and progression. Dihydroartemisinin (DHA) can inhibit the level of ferroptosis in various diseases. Therefore, the present study investigated whether DHA could inhibit seizures and display neuroprotective impacts by impeding ferroptosis.

Methods

In the KA-induced epileptic mouse model, the effects of DHA on epileptic behavior, cognitive function, and hippocampal neuronal damage were observed. Using both in vivo and in vitro models, the impact of DHA on neuronal injury and ferroptosis-related markers was investigated. Techniques including molecular docking, Western Blot, immunofluorescence, and CHIP-qPCR were utilized to analyze

SUBMITTER: You Z 

PROVIDER: S-EPMC12921727 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature