Vitamin D Reprograms Non-Coding RNA Networks to Block Zika Virus in Human Macrophages.

ABSTRACT: Background: Zika virus (ZIKV), a mosquito-borne flavivirus, is associated with congenital malformations and neuroinflammatory disorders, highlighting the need to identify host factors that shape infection outcomes. Macrophages, key targets and reservoirs of ZIKV, orchestrate both antiviral and inflammatory responses. Methods: Vitamin D (VitD) has emerged as a potent immunomodulator that enhances macrophage antimicrobial activity and regulates inflammation. To investigate how VitD shapes macrophage responses to ZIKV, we reanalyzed publicly available RNA-seq and miRNA-seq datasets from monocyte-derived macrophages (MDMs) of four donors, differentiated with or without VitD and subsequently infected with ZIKV. Results: Differential expression analysis identified long non-c

SUBMITTER: Ramirez-Mejia JM 

PROVIDER: S-EPMC12921728 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature