Changes in Cerebellar Multiunit Activity Associated with Ventrolateral Striatal Injury During Spontaneous Motor Behavior.

ABSTRACT: Background: Parkinsonism entails pronounced basal ganglia dysfunction, but emerging research suggests that broader subcortical networks, specifically the cerebellum, play a vital role in functional motor compensation following circuit-level destabilization. This study sought to characterize the electrophysiological dynamics of Multi-Unit Activity (MUA) amplitude in Crus II, the dentate nucleus (DN), and the inferior olive (IO) following a focal mechanical lesion of the ventrolateral striatum (VLS) as a circuit-level perturbation model during spontaneous behaviors. Methods: Bilateral mechanical VLS lesions were induced in 24 male Wistar rats. MUA signals were chronically recorded over a four-week protocol during self-grooming, horizontal locomotion, and rearing behaviors. R

SUBMITTER: Viveros-Martinez I 

PROVIDER: S-EPMC12921778 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature