Polygenic Index for Sleep Duration and Brain Changes over Time.

ABSTRACT:

Background

Sleep is a complex physiological process, crucial for cognitive functioning, emotional regulation, and overall health. Recent advances in genomics and neuroimaging have illuminated the intricate relationship between genetics, sleep architecture, and brain changes. This study investigated the association between sleep duration genetics, through a Sleep Duration Polygenic Index (Sleep PGI), and brain changes (total cortical thickness, white matter volume, gray matter volume, white matter hyperintensities volume) in cognitively healthy adults aged 20-80 years old.

Methods

Using longitudinal data from the Reference Ability Neural Network (RANN) and Cognitive Reserve (CR) studies, we examined the impact of Sleep PGI on brain measures (total cortical thickness, gray mat

SUBMITTER: Angeliki T 

PROVIDER: S-EPMC12921902 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature