Analysis of HERV-K (HML2) Expression in Colorectal Cancer Samples.

ABSTRACT:

Background

HML-2 subgroup mobile genetic elements of the HERV-K family were described to participate in carcinogenesis processes, but their expression and epigenetic regulation in molecular subtypes of colorectal cancer (CRC) remain partly characterized. The present study aimed to evaluate the expression of HML-2 elements using RNA-sequencing data in paired tumor and normal intestinal tissue samples from 63 patients with CRC to identify patterns of the retrotransposons' activity in different molecular subtypes (CMSs).

Methods

RNA-sequencing and DNA methylation data were analyzed for paired CRC and normal tissue samples. HERV-K expression was assessed using three bioinformatics tools: Telescope (version 1.0.3), TEtranscripts (version 2.2.3), GeneTEFlow (version 2020). Molecul

SUBMITTER: Obrezanenko VS 

PROVIDER: S-EPMC12922068 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature