Tumor-intrinsic PD-L1 drives lung cancer progression in response to TLR stimulation by promoting autophagy through the TRAF6-BECN1 signaling axis.

ABSTRACT:

Background

Programmed death-ligand 1 (PD-L1, CD274) is well known for its immunosuppressive function within the tumor microenvironment; however, its tumor cell-intrinsic roles remain incompletely characterized. Emerging evidence suggests that PD-L1 may regulate oncogenic processes beyond immune evasion. This study aimed to define the intrinsic functions of PD-L1 in non-small cell lung cancer (NSCLC), with a focus on autophagy and metastasis-related signaling pathways.

Methods

Integrated transcriptomic analyses of patient-derived NSCLC specimens were performed to evaluate associations between CD274 expression and oncogenic gene signatures. CRISPR-Cas9-mediated knockout and plasmid-driven overexpression of PD-L1 were conducted in H460 and A549 cell lines to assess proliferatio

SUBMITTER: Sung Y 

PROVIDER: S-EPMC12922217 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature