Associations of body mass index on worsening of heart failure and mortality in patients with heart failure and reduced left ventricular ejection fraction: a 10-year follow-up study (a NorthStar substudy).

ABSTRACT:

Background

Obesity is prevalent in patients with heart failure with reduced ejection fraction (HFrEF). With the advent of glucagon-like peptide 1 analogues, understanding the relationship between body mass index (BMI) and clinical outcomes in HFrEF is crucial.

Objective

This study investigated whether a BMI > 27 kg/m² is associated with higher rates of all-cause mortality, cardiovascular mortality, and heart failure (HF) hospitalization in patients with HFrEF.

Methods

A total of 1017 clinically stable and medically optimized HFrEF patients from the NorthStar study (enrolled 2005-2009) were analyzed. Patients were followed until 2023 using Danish nationwide registries. The primary outcome was all-cause mortality, while secondary outcomes included cardiovascu

SUBMITTER: Malmborg M 

PROVIDER: S-EPMC12922329 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature