Can a host-response bacterial-viral classifier safely guide antibiotic avoidance in COVID-19? A diagnostic accuracy study in hospitalized adults.

ABSTRACT:

Background and objectives

The MeMed BV^® test distinguishes bacterial from viral infections by integrating circulating levels of TRAIL, IP-10, and CRP into a likelihood score. Pre-COVID studies reported high diagnostic accuracy in respiratory infections, but evidence in adults hospitalized with SARS-CoV-2 is sparse. To evaluate the ability of MeMed BV to identify hospitalized COVID-19 patients who could be safely managed without antibiotics.

Methods

We included adults with PCR-confirmed SARS-CoV-2 infection from two prospective Norwegian cohorts (October 2020-April 2023). The reference standard for true viral infection was a composite safety outcome: 30-day survival, no readmission within 30 days, and no antibiotic exposure before, during, or after hospitalization.

SUBMITTER: Markussen DL 

PROVIDER: S-EPMC12922441 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature