O-Acetyl-Serine Supplementation Enhances Insulin Secretion and Improves Postprandial Glycaemia in Lean and Prediabetic Mice.

ABSTRACT: Type 2 Diabetes (T2D), often preceded by reversible prediabetes, poses a major health challenge. Targeting early glucose dysregulation is a promising preventive strategy. Amino acids and their derivatives are emerging as key regulators of glucose homeostasis. Here, we investigate the role of O-acetyl-serine (OAS), a serine-derived metabolite produced by plants and microbes, including those of the gut microbiota, in glycaemia regulation. We developed a targeted method to quantify OAS in plasma and tissues, showing that it enters circulation and transiently accumulates in the pancreas. In vivo, OAS specifically and dose-dependently improves postprandial glycaemia in lean mice. Mechanistically, OAS acts as a glucose-dependent insulin secretagogue: a single oral dose increased pancreatic OAS l

SUBMITTER: Benatar C 

PROVIDER: S-EPMC12922573 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature