Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs.

ABSTRACT:

Purpose

To quantitatively assess the bias in the intravoxel incoherent motions (IVIM)-derived pseudo-diffusion volume fraction (f) caused by the differences in relaxation times between the tissue and fluid compartments, and to develop a two-dimensional (b-value-TE) fitting approach for simultaneous T2 and IVIM parameter estimation along with an optimal acquisition protocol for the relaxation-compensated T2-IVIM imaging in the liver.

Methods

Simulations were conducted to investigate the TR- and TE-dependent bias in f when using the IVIM model, and to evaluate the applicability of the 2D T2-IVIM model for reducing this bias. The numerical findings were then validated using the in vivo IVIM data from four healthy volunteers on a 3-Tesla MRI scanner. Finally, a numerical framewo

SUBMITTER: Stabinska J 

PROVIDER: S-EPMC12922574 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature