Association between myosteatosis and survival of patients with esophageal and gastro-esophageal junction cancer: a meta-analysis.

ABSTRACT:

Background

Myosteatosis, a marker of fatty infiltration in skeletal muscle, has emerged as a potential prognostic factor in various cancers. However, its association with survival in patients with esophageal cancer (EC) or gastro-esophageal junction cancer (GEC) remains uncertain. This meta-analysis aimed to evaluate the predictive value of myosteatosis for survival of this patient population.

Methods

A systematic search of PubMed, Embase, and Web of Science was conducted through May 14, 2025. Studies reporting overall survival (OS) and/or progression-free survival (PFS) in patients with EC or GEC, with outcomes stratified by baseline myosteatosis status, were eligible for inclusion. To account for inter-study variability, pooled hazard ratios (HRs) and corresponding 95% con

SUBMITTER: Wang W 

PROVIDER: S-EPMC12922584 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature