PH-Responsive Peptide-Polymer Hydrogel for Biofilm Disruption.

ABSTRACT: Biofilm formation presents a significant challenge in chronic infections as it enables bacteria to resist conventional antibiotics and thrive in various areas of the body. The treatment is further hurdled by the acidic environment of biofilms due to anaerobic glycolysis of bacteria and the accumulation of acidic byproducts. Therefore, there is a need for the development of antimicrobial materials that can selectively and preferentially eradicate biofilms in the acidic environment. Toward this aim, this study explores the use of acid-responsive double-network peptide-polymer hydrogels encapsulated with antimicrobial peptides to effectively target and disrupt biofilms. The hydrogel consists of two essential components: a self-assembling peptide nanofiber containing a non-natural ionic amino

SUBMITTER: Asokan-Sheeja H 

PROVIDER: S-EPMC12922601 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature