Outcomes and risk factors of hemorrhage in patients with resected brain metastases.

ABSTRACT: Brain metastases (BrMs) may present with intralesional or intracranial hemorrhage (ICH), yet risk factors and outcomes remain unclear. This monocentric cohort study at Germany's largest neurosurgical clinic included 973 adults undergoing BrM resection (2010-2024), with histopathologically confirmed etiologies and known tumor burden. Based on pre-operative CT or MRI, 880 patients were categorized as non-hemorrhagic (non-hBrM), presenting with intralesional hemorrhage (hBrM), or with ICH of ≥30 mm diameter (ICH-BrM). Risk factors for hBrM and ICH-BrM were assessed, and overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meyer methods. Of 880 patients, 560 (63.6%) were non-hBrM, 243 (27.6%) hBrM, and 77 (8.8%) ICH-BrM. ICH-BrM had larger tumor volume (21 cm

SUBMITTER: Guelen MS 

PROVIDER: S-EPMC12922642 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature