Body mass index and colorectal cancer recurrence and mortality: A nationwide cohort study in Denmark.

ABSTRACT: Obesity may exacerbate colorectal cancer (CRC) prognosis, yet previous studies have shown inconsistent findings due to methodological limitations. In this nationwide cohort study, we investigated the association between body mass index (BMI) on CRC recurrence and mortality, while examining the influence of demographic, clinical, and socioeconomic characteristics. From the Danish Colorectal Cancer Group database and population-based registries, we assembled a cohort of stage I-III CRC patients who underwent curative intent surgery between 2002 and 2020. We identified 5-year CRC recurrence and mortality using validated algorithms and registries. We estimated cumulative incidence functions (CIFs) and applied Cox regression modeling BMI via splines and categorically. We examined synergistic ef

SUBMITTER: Hjorth CF 

PROVIDER: S-EPMC12922645 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature