Surface engineering <i>'liquid-like'</i> solid surfaces with nitric oxide releasing polymers to combat biofouling.

ABSTRACT: 'Liquid-like' solid surfaces that overcome the limitations of lubricant-infused slippery surfaces, have garnered attention as passive antibiofouling coatings for biomedical applications. However, lack of intrinsic bioactivity limits its ability to eradicate planktonic microbes and prevent platelet activation-leading to microbial contamination and thrombosis that results in device occlusion, and patient mortality. Thus, in this work, we exploit the passively antifouling properties of 'liquid-like' solid surfaces and integrate it with the vasodilatory, bioactive gasotransmitter nitric oxide (NO), secreted by the endothelium to create a novel combinatorial anti-biofouling platform. Bio-inspired NO donor molecules offer both antibacterial and antithrombotic functionalities, addre

SUBMITTER: Shome A 

PROVIDER: S-EPMC12922648 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature