Human Hearts Intrinsically Increase Cardiomyocyte Mitosis After Myocardial Infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes within the human heart. Although cardiomyocytes undergo mitosis during early development, most cardiomyocytes cease cell cycling soon after birth. In contrast, rodent MI models have shown that cardiomyocytes increase mitosis in response to ischemia; however, this has not been shown in humans.

Methods

Using a unique premortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single-nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human cardiomyocyte mitosis post-MI.

Results

We show that adult human cardiomyocytes exhibit increased mitosis and cytokinesis in response to ischemia

SUBMITTER: Hume RD 

PROVIDER: S-EPMC12922688 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature