Engineering controlled-release steroid therapeutics: fabrication and molecular design of self-assembled microparticles.

ABSTRACT: Steroids, specifically bile salts and corticosteroids, treat bile synthesis disorders, liver dysfunction, and inflammation. However, these water-soluble steroid drugs are rapidly cleared from the desired sites of action in the body, necessitating multiple doses. Therefore, the development of particle-based steroid medications that offer elongated therapeutic activity is of paramount medical importance. Accordingly, steroid microparticles were developed via three fabrication processes in this work, where a metal or an organic acid facilitates steroid microparticle formation. Particles fabricated using these methods exhibit consistent shape, size, and crystallinity. Furthermore, results from our coarse-grained computational model show that hydrogen bonding dictates steroid monomer-monomer in

SUBMITTER: Akanbi OD 

PROVIDER: S-EPMC12922742 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature