Dietary inflammatory index in relation to incident CKD: A prospective study of UK Biobank participants.

ABSTRACT:

Background and objectives

The relationship between increased inflammatory diet patterns and chronic kidney disease (CKD) remains unknown and has not been investigated in large cohorts.

Methods

A total of 154,070 adults registered in UKB database were enrolled and followed, free of CKD and eGFR > 90 mL/min/1.73 m2 at baseline. The energy-adjusted dietary inflammatory index (E-DII) was evaluated using the 24-h recall diet. Cox proportional hazards regression models were used, adjusting for confounders such as demographic indicators, socioeconomic status, and lifestyle factors. Additionally, a subgroup analysis was conducted to investigate the relationship with incident CKD. The nonlinear relationship between E-DII and CKD risk was analyzed using a restricted cubic spline.

R

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12923052 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature