Medication adherence trajectories and association with risk factors and clinical outcomes in type 2 diabetes treatment.

ABSTRACT:

Background

Monitoring medication adherence and main clinical outcomes changes in type 2 diabetes (T2D) is essential for optimal patient management. This study aimed to compute and evaluate medication adherence in its three process phases among T2D patients treated with oral antidiabetic (OAD) medications assessing association with main clinical outcomes.

Methods

This retrospective cohort study included newly diagnosed T2D patients initiating OAD therapy within 2015-2019 identified from the Nivel Primary Care Database (Nivel-PCD) in the Netherlands. Initiation was operationalised as ≥2 OAD prescriptions within follow-up. Implementation was quantified monthly using the Continuous Multiple-interval Measure of Medication Availability (CMA9). Group-based trajectory modelling (k-m

SUBMITTER: Mucherino S 

PROVIDER: S-EPMC12923057 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature