Integrating phytochemical analysis and experimental validation of Ziziphus jujuba seed powder and oil to ameliorate CCl4-induced liver fibrosis in sprague dawley rats.

ABSTRACT: Liver fibrosis, a consequence of chronic liver injury, is characterized by excessive accumulation of the extracellular matrix, oxidative stress, and activation of hepatic stellate cells. This study evaluated the effectiveness of Ziziphus jujuba (Z. jujuba) seed powder and seed oil, both separately and in combination, in alleviating CCl4-induced liver fibrosis, and linked the in vivo effects to their phytochemical profiles. The seed powder extracts, using acetone and ethanol, showed significant antioxidant activity, with DPPH values reaching up to 90.13%, and exhibited a high phenolic content of 79.57 mg GAE/g in the ethanol extract. Gas chromatography-mass spectrometry (GC-MS) analysis identified several bioactive compounds, including derivatives of 1,4-benzenedicarboxylic acid (30.46% in

SUBMITTER: Tanvir L 

PROVIDER: S-EPMC12923133 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature