The Impact of Gut Microbiota on Immunoglobulin A Nephropathy through the Mediation of Specific Immune Cells: A Mendelian Randomization Study.

ABSTRACT:

Introduction

Gut microbiota alterations had been implicated in the pathogenesis of IgA nephropathy (IgAN). However, how did the gut microbiota participated in the onset and development of IgAN was unclear. This study investigated the causal effects of gut microbiota on IgAN and identifies potential mediators, including lipids, inflammatory factors, metabolites, and immune cells.

Methods

Genome-wide association study (GWAS) data for gut microbiota, IgAN, and mediators were analyzed. Two-sample Mendelian randomization (MR) assessed the causal relationship between gut microbiota and IgAN, followed by two-step MR mediation analysis to identify indirect effects via mediators. Mediation effects were quantified using the coefficient product method.

Results

MR analysis identi

SUBMITTER: Wan J 

PROVIDER: S-EPMC12923258 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature