Nonlinear relationship between sleep midpoint and osteoarthritis: a cross-sectional study in US adults.

ABSTRACT:

Background

Osteoarthritis (OA) is a common chronic degenerative joint disease globally. While sleep-related factors are linked to its pathogenesis, the specific association and nonlinear characteristics between sleep midpoint (the midpoint of the sleep cycle) and OA remain unclear.

Methods

Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES 2015-2020). Sleep midpoint was calculated from self-reported weekday bedtime and wake-up time. Restricted cubic spline (RCS) models analyzed the relationship between sleep midpoint and OA, adjusted for demographic, lifestyle, and clinical covariates. Subgroup analyses and propensity score matching verified result robustness.

Results

A total of 7640 participants were included in this s

SUBMITTER: Yang H 

PROVIDER: S-EPMC12923419 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature