Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels.

ABSTRACT:

Objective

Trans-Chalcone (TC) is an anti-inflammatory flavonoid that reduces hyperalgesia by targeting nuclear factor κB and inflammasome in gout arthritis model. However, a direct modulation of nociceptors by TC has never been investigated, which was the aim of the present study.

Methods

Experimental models of overt pain-like behaviors were applied as the stimuli-induced behavior depends, at least in part, on nociceptive neuron activation by the stimuli themselves making them suitable to investigate if a drug candidate can inhibit nociceptive neuron activation. The selected models involve transient receptor potential (TRP) vanilloid 1 (V1)⁺ and TRP ankyrin 1 (A1)⁺ nociceptive neuron activation.

Results

TC (10 mg/kg, per oral, 30 min pretreatment

SUBMITTER: Piva M 

PROVIDER: S-EPMC12923438 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature