Neuroprotective Mechanisms of Ficus deltoidea in an Alzheimer's Disease-Like Rat Model: Targeting Tau Hyperphosphorylation Through Glycogen Synthase Kinase-3 Beta and Protein Phosphatase 2A Regulation.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by memory loss, neurodegeneration, amyloid plaque accumulation and tau hyperphosphorylation. Dysregulation of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2 A (PP2A) plays a pivotal role in tau pathology, contributing to synaptic dysfunction and memory impairment. Current AD medications offer limited palliative care, underscoring the need for multifaceted therapeutic strategies. Ficus deltoidea (FD), a medicinal plant renowned for its antioxidant and anti-inflammatory properties, has demonstrated neuroprotective effects, however, its specific role in modulating tau-associated proteins in AD remains underexplored. Thus, this study investigated the neuroprotective properties of FD on the spatia

SUBMITTER: Manoharan SD 

PROVIDER: S-EPMC12923462 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature