Mapping fibrosis in colorectal liver metastases (CRLM) with gadobenate dimeglumine-enhanced MRI: prognostic implications and imaging biomarkers.

ABSTRACT:

Purpose

Development of fibrosis in treated colorectal liver metastases (CRLM) could be supposedly used for the estimation of both treatment response and prognosis. This study aimed to investigate the association between post-chemotherapy, fibrosis-related progressive gadolinium enhancement of CRLM on MRI and overall survival.

Material and methods

A retrospective study of 97 CRLM patients (68 M, mean age 62.3 ± 10.71 years) who underwent between 2017 and 2022 preoperative gadobenate dimeglumine (Gd-BOPTA) - enhanced MRI after chemotherapy. Tumor and liver enhancement were quantified using Signal Intensity Change Percentages (SICP) across 5-min and 60-min delay phases, along with the Tumor-to-Liver Enhancement Index (TLEI) to estimate fibrosis within CRLM. A subset of 18 patie

SUBMITTER: Morawska I 

PROVIDER: S-EPMC12923479 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature