Association of reduced REM sleep with mortality in adults with coronary artery disease and obstructive sleep apnea in the RICCADSA cohort.

ABSTRACT:

Purpose

Reduced rapid-eye movement (REM) sleep has been linked to increased mortality in the general population. We investigated whether diminished REM sleep is associated with higher mortality in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA).

Methods

This secondary analysis of the RICCADSA trial included 356 revascularized CAD patients with OSA (apnea-hypopnea index [AHI] ≥ 15 events/h) and total sleep time (TST) ≥ 240 min on baseline polysomnography. Reduced REM sleep was defined as the lowest quartile of REM percentage. Cox proportional hazards models assessed the association between reduced REM sleep and mortality over a median 4.7-year follow-up.

Results

The lowest REM quartile corresponded to 8.7% of TST. Participants with reduced R

SUBMITTER: Balcan B 

PROVIDER: S-EPMC12923483 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature