Dual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa.

ABSTRACT: The transition between motility-associated acute infection and biofilm-associated chronic infection is crucial for bacterial proliferation and survival within hosts. This process of transition can be influenced by various host and environmental cues, however, whether bacteria could actively modulate the switch remains poorly understood. Here we identify a novel enoyl-CoA hydratase/isomerase, PA0744 (designated as DspII), which is co-upregulated with the previously characterized enoyl-CoA hydratase/isomerase DspI in a cell density-dependent manner to induce chronic-to-acute virulence switch in Pseudomonas aeruginosa. The two proteins form a heterocomplex that synthesizes the DSF-family quorum sensing signal cis-2-decenoic acid (CDA), which positively regulates the expression of the phosphod

SUBMITTER: Huang J 

PROVIDER: S-EPMC12923603 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature