Histatin-1 promotes the expression of markers associated with odontoblastic differentiation in the dental pulp and apical papilla.

ABSTRACT: Complex tooth injuries, including dental caries, require the reestablishment of tissue architecture and functionality through the regeneration of cellular populations that enable tertiary dentin formation and the reestablishment of vascular and neural components. Among these cellular populations, the odontoblasts play a critical role, as they are responsible for dentin formation and maintenance, and can differentiate from stem cells of the dental pulp and apical papilla. We previously demonstrated that Histatin-1, a salivary peptide with wound-healing properties, enhances the mineralizing activity of primary mesenchymal cells from immature permanent teeth. Here, we demonstrate that Histatin-1 upregulates odontoblastic differentiation markers, including dentin sialophosphoprotein (DSPP) and

SUBMITTER: Silva P 

PROVIDER: S-EPMC12923681 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature