Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.

ABSTRACT: Major depressive disorder is a highly prevalent psychiatric condition characterized by diverse symptom profiles and variable treatment responses. The hippocampus has long been implicated in its pathophysiology, yet most human neuroimaging studies have treated it as a unitary structure, overlooking the distinct cytoarchitecture and connectivity of its subfields. Preclinical research demonstrates that subfields such as cornu ammonis 1 (CA1) and the dentate gyrus (DG) are differentially involved in stress susceptibility and antidepressant response. However, limited spatial resolution of conventional human neuroimaging has constrained in vivo characterization of these subfields and testing of translational hypotheses in humans. While advances in high resolution 3 tesla (T) imaging have improve

SUBMITTER: Jubeir J 

PROVIDER: S-EPMC12923689 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature