The value of immunogenic cell death-related gene model in the prognosis of gastric cancer.

ABSTRACT: Immunogenic cell death (ICD) is a form of regulatory cell death that has been obtained growing attention for its role in the treatment and prognosis of tumors. This study aims to further investigate the value of immunogenic cell death-related genes (ICDRGs) in prognostic of GC. We obtained the stomach adenocarcinoma (STAD) dataset from the Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) database, got ICDRGs from the GeneCards database, and utilized LASSO regression to construct a prognostic model. Based on the median risk score, patients were separated into high-risk and low-risk groups and differential gene expression analysis related to prognosis was obtained. We further studied the possible mechanisms, biological characteristics, and pathways of genes in differ

SUBMITTER: Lang Y 

PROVIDER: S-EPMC12923713 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature