Depression and anxiety in interstitial lung disease: a systematic review, meta-analysis and Mendelian randomization.

ABSTRACT:

Objective

To investigate the prevalence of depression and anxiety in interstitial lung disease (ILD) and reveal whether ILD is causally associated with depression and anxiety via Mendelian randomization (MR).

Methods

Eligible studies were identified and selected from Web of Science, PubMed and Scopus. The pooled prevalence of depression and anxiety in ILD, as well as the clinical characteristics of ILD with depression or anxiety, were assessed. Sensitivity analyses, subgroup analyses and meta-regression were applied for heterogeneity assessments. Data of MR analysis were derived from the UK biobank and Finngen cohort, and the inverse variance weighting approach was selected as the main approach for causality evaluation.

Results

A total of 35 studies were included in t

SUBMITTER: Du D 

PROVIDER: S-EPMC12923813 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature