Biological underpinnings and genetic predisposition to schizophrenia within microrna-137 regulatory pathways across brain development.

ABSTRACT: Previous studies have evaluated the role of the microRNA-137 (miRNA137) regulatory pathway in schizophrenia by using in silico or in vitro predicted target genes. These approaches do not capture the dynamic spatiotemporal nature of the miRNA137 regulatory pathway or tend to overestimate direct miRNA binding sites. To provide a more accurate representation of the miRNA137 pathway during human brain development, we evaluated the biological functionality of direct ex vivo miRNA137 targets previously documented in the early prenatal and adult brain. We studied the role of differential expression and genetic predisposing variation to schizophrenia and related disorders within these miRNA137 targets by gene set enrichment analyses (GSEA) and gene-set based polygenic score predictions in an indep

SUBMITTER: Stella C 

PROVIDER: S-EPMC12923818 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature