Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state.

ABSTRACT: Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture features, could advance our understanding of the underlying disease perceptual mechanisms that mediate susceptibility to psychosis. In this study, we aim a) to investigate the utility of brain texture features for the prediction of VisDys in recent onset psychosis (ROP) and clinical high-risk syndromes for psychosis (CHR-P), respectively, b) to test prediction models established in ROP and CHR-P in an independent validation sample with recent onset depression (ROD) diagnoses and c) to test for symptom expression related brain features associated with VisDys. sMRI were acquired in a training sample including 1

SUBMITTER: Lencer R 

PROVIDER: S-EPMC12923831 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature