Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms.

ABSTRACT: Epidemiological research suggests that maternal immune activation (MIA) during early gestation is a significant risk factor for neurodevelopmental and psychiatric disorders in offspring. Epigenetic factors and chromatin-related phenomena remain highly dynamic throughout prenatal and early postnatal development, offering a substrate through which environmental insults can exert lasting effects on gene regulation. Here, we used a mouse MIA model induced by infection with a mouse-adapted influenza A/WSN/33 (H1N1) virus to investigate the long-term molecular consequences of maternal infection on adult offspring. To separately assess prenatal and postnatal effects of MIA, we cross-fostered half of the pups from each influenza-infected or mock-treated dam at birth. We then profiled histone modif

SUBMITTER: Zhu B 

PROVIDER: S-EPMC12923905 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature