TNF-⍺-mediated myeloid-instructed CD14⁺CD4⁺ T cells are associated with poor survival in lung adenocarcinoma.

ABSTRACT: The tumor microenvironment is composed of diverse immune populations that can either support anti-tumor immunity or promote tumor progression. Myeloid cells are major drivers of immunosuppression, yet therapies targeting them have shown limited success. To uncover mechanisms underlying myeloid-driven immune suppression, we performed spatial multi-omics analyses of non-small cell lung cancer (NSCLC). Independent of oncogenic driver status, tumors stratify into lymphoid-enriched, myeloid-enriched, and mixed immune-infiltrated subtypes. In tumor and adjacent non-malignant lungs, we identify myeloid-instructed CD14⁺CD4⁺ T cells. These cells arise through trogocytosis adopting an atypical phenotype. In lymphoid-enriched tumors, high infiltration of CD14⁺CD4

SUBMITTER: Marceaux C 

PROVIDER: S-EPMC12923953 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature