Prior Cancer and Survival in Patients With Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Importance

Esophageal squamous cell carcinoma (ESCC) is highly prevalent in Asian populations and carries a poor prognosis. With growing numbers of cancer survivors, the prognostic impact of prior cancer in ESCC remains unclear. Most existing data are derived from Western cohorts dominated by adenocarcinoma, limiting generalizability to Asian populations.

Objective

To evaluate whether prior cancer is associated with overall survival (OS) and esophageal cancer-specific mortality (ECSM) in a nationwide Korean ESCC cohort.

Design, setting, and participants

A retrospective cohort study of patients with newly diagnosed ESCC across 19 tertiary hospitals in Korea from 2005 to 2017 was conducted. Follow-up was completed in 2017. Data were reanalyzed in August 2025. Exclusion

SUBMITTER: Yu S 

PROVIDER: S-EPMC12924099 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature