Downregulation of <i>S100a8</i> mitigates fibrosis in skeletal muscles affected by Marfan syndrome.

ABSTRACT: This study investigated the potential of eccentric training in attenuating the deleterious effects of Marfan syndrome on skeletal muscles. Marfan syndrome and wild-type mice were divided into a trained and a control group; the former performed a downhill running protocol for 8 weeks. Morphological, molecular, and functional analyses were performed. Based on RNA sequencing analyses, the gastrocnemius and plantaris muscles were transfected with S100a8-shRNA (short hairpin RNA) and analyzed after 21 days. The muscle wet weight normalized to body weight and the percentage of myofibers with a higher cross-sectional area were lower in the muscles of Marfan syndrome mice than in wild-type mice. Marfan syndrome mice showed increased fibrosis and number of rounded myofibers, whereas eccentri

SUBMITTER: Santos AR 

PROVIDER: S-EPMC12924125 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature