In-Depth Analysis of the Intravitreal Biocompatibility of Polyethylene Glycol of Different Molecular Weight in an In Vivo Porcine Model.

ABSTRACT:

Purpose

Polyethylene glycol (PEG)ylation is an established, increasingly used method to prolong the half-lives of active compounds applied intravitreally. However, the biocompatibility of high doses of high molecular weight PEG has never been systematically assessed in a translational in vivo model. The aim of this study was to evaluate the intraocular inflammatory and pro-angiogenic response as well as structural and functional retinal alterations after the intravitreal injection of PEG of varying molecular weight injected intravitreally in a large animal in vivo pig model.

Methods

This cohort study includes 12 pigs divided into 4 cohorts. Each cohort received an intravitreal injection of either 0.1 mL with 400 mg/mL of PEG-400, PEG-2000, PEG-40000 or an injection of balanc

SUBMITTER: Hammer M 

PROVIDER: S-EPMC12924145 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature