Systematic Search for Blood-Brain Barrier Modulating Peptides Based on Exhaustive E-Cadherin Domain-Domain Docking.

ABSTRACT: E- and VE-cadherins are among proteins forming intercellular junctions that are a crucial component of cell-cell adhesion in the intercellular junctions of the biological barriers (i.e., blood-brain barrier (BBB) and intestinal mucosa barrier). The BBB prevents the delivery of large therapeutic molecules from the systemic circulation to the central nervous system. Previously, HAV and ADT peptides that were identified from the extracellular-1 domain (EC1 domain) of E-cadherin successfully modulated the BBB intercellular junctions to improve the permeation of molecules across the BBB both in vivo and in vitro. Here, we use computational methods to perform a more exhaustive and systematic search for novel peptides that can effectively interfere with E-cadherin interactions to enhance the perm

SUBMITTER: He J 

PROVIDER: S-EPMC12924148 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature