Lack of renal NHE1 exacerbates lithium-induced nephrogenic diabetes insipidus.

ABSTRACT:

Aims

The sodium-hydrogen exchanger isoform 1 (NHE1) is important for transepithelial Na⁺/H⁺ transport, intracellular pH, and cell volume regulation. NHE1 also transports Li⁺, preferably compared to NHE3, and the lack of NHE3 does not affect renal Li⁺ clearance. Therefore, we hypothesized that NHE1 plays a critical role in mediating renal Li⁺ effects.

Methods

We generated mice lacking NHE1 in epithelial cells throughout the kidney tubule/collecting duct (NHE1^KS-KO). Physiological phenotyping of NHE1^loxlox and NHE1^KS-KO mice was performed under a control diet and after mice received a LiCl-containing diet for 4 weeks. Tissue was harvested at baseline and at the end of the experimental perio

SUBMITTER: Blanco G 

PROVIDER: S-EPMC12924156 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature