Central versus peripheral veno-arterial extracorporeal membrane oxygenation during lung transplantation: a systematic review and meta-analysis.

ABSTRACT:

Introduction

The use of extracorporeal membrane oxygenation (ECMO) during lung transplantation has progressively expanded and, in many centers, replaced conventional cardiopulmonary bypass. However, it remains unclear whether central or peripheral veno-arterial (VA) ECMO provides superior postoperative outcomes. This study aimed to compare central VA-ECMO (cVA-ECMO) and peripheral VA-ECMO (pVA-ECMO) during lung transplantation, with a focus on survival, primary graft dysfunction grade 3 (PGD3), postoperative ECMO support, and postoperative morbidity.

Methods

Three databases were assessed through November 2025. Five retrospective observational studies including 866 patients were included. Overall survival was analyzed using reconstructed individual patient data derived from K

SUBMITTER: Delgado LM 

PROVIDER: S-EPMC12924189 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature