Genetic associations of circulating plasma proteins with cardiometabolic diseases.

ABSTRACT:

Background

Cardiovascular disease is the leading cause of death worldwide, and its risk is closely linked to metabolic abnormalities. Through summary-data-based mendelian randomization and colocalization analysis, we investigate the causal relationships between plasma proteins, six cardiovascular diseases (atrial fibrillation, coronary artery disease, heart failure, venous thromboembolism, peripheral artery disease and stroke), and 19 metabolic traits (including anthropometric phenotypes, blood pressure, glycemic phenotypes, inflammatory phenotypes, kidney-related phenotypes, lipidemic phenotypes, and liver-related phenotypes).

Results

We identify 49 proteins genetically associated with cardiovascular diseases, validated across two proteomic platforms. Among them, 35 are als

SUBMITTER: Zhou R 

PROVIDER: S-EPMC12924215 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature