Vacuole and mitochondria patch (vCLAMP) protein Mcp1 reduces the pathogenesis of Candida albicans by impeding the function of Cap1-mediated oxidative stress response.

ABSTRACT:

Background

Vacuole and mitochondria patch (vCLAMP) is a novel organelle membrane contact site. The vCLAMP protein Mcp1 plays a crucial role in cellular signaling and homeostasis. However, its role in the virulence of Candida albicans remains to be elucidated.

Results

This study explored the function of Mcp1 in the oxidative stress response of C. albicans. Fluorescence co-localization and immune transmission electron microscopy results suggested that Mcp1 was located on vacuolar and mitochondrial membranes. RNA sequencing and Gene Ontology enrichment analyses showed that the deletion of MCP1 inhibited the expression of genes related to the oxidative stress response, such as GLR1, TRR1, and SOD2, in C. albicans. In addition, the deletion of MCP1 diminished the activity of anti

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12924228 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature