Strengthening Primary Care for Recognising and Treating Depression (SPiRiT-D): a study protocol for a cluster randomised controlled effectiveness-implementation trial of collaborative care for depression.

ABSTRACT:

Background

The effectiveness of collaborative care for treating depression in primary care has been well-established in high-income countries and, more recently, in a few trials in low- and middle-income countries (LMICs). However, evidence for its effectiveness, costs and how it can be implemented in 'real-world' settings within resource-constrained health systems in LMICs is currently limited. We aim to investigate the implementation, clinical and cost-effectiveness of a contextually adapted collaborative care model for depression in primary care clinics in Pakistan.

Methods

A hybrid type-II effectiveness-implementation cluster randomised controlled trial with embedded process and economic evaluations will be conducted. Twenty-four primary care clinics located in socioecon

SUBMITTER: Faisal MR 

PROVIDER: S-EPMC12924309 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature